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Meniere's Syndrome

 

Timothy C. Steroids are commonly prescribed for sudden hearing loss as well as for autoimmune inner ear disease and vestibular neuritis. The purpose of this page is to outline the usual methodology.

We do not discuss their effectiveness or the validity of their indications. There is very little difference with respect to the ultimate results with these drugs and side effects, but they differ in potency and duration of action, and for this reason, the dose must be adjusted.

Oral decadron would seem to us to be a poor choice for a condition in which rapid effects are desirable such as acute hearing loss or vestibular neuritis, as due to it's long half life, it takes 20 days to reach steady state. Of course, one can adjust one's protocol to give more drug at the beginning, as is the case for the "medrol dose pack".

The most common method of administration is by mouth. We will not discuss intravenous administration faster and stronger, sometimes used for situations where symptoms are very severe such as bilateral deafness associated with autoimmune inner ear disease. Administration through the ear-drum is discussed elsewhere. This method has the advantage of much less side effects, but the disadvantages of higher expense and the need for a subspecialty visit for injection through the ear drum.

For the oral method, there are four common protocols that we use in our clinic :. The easiest, safest, and most convenient method of trying steroids is to use a medrol methylprednisolone dose pack. This is a card that contains 6 days of steroids, with less provided each day.

The gradual decrease in the amount of steroids each day is called a "taper". The reason to do this is to allow the patient's adrenal glands, which are usually suppressed by the steroids, to gradually return to supplying steroids to the patient on their own.

Medrol is slightly stronger than prednsone, so to convert this into "prednisone", when using the 4 mg dose-pack, one just has to multiple by 5. In other words, the medrol dose pack is the equivalent of 30 mg of prednisone, tapering down to 0 over a week. For persons in whom a larger amount of steroids is indicated a longer protocol and more intense protocol is selected. Longer pulses require longer tapers. Checking the blood pressure to make sure it is not dropping too low and follow up visits during the taper period are often required.

Some patients are "steroid dependent". For example, whenever the steroid dose is decreased below a threshold, hearing starts to deteriorate again. In patients like this, an attempt is made to find a steroid sparing replacement drug such as methotrexate or Enbrelbut in the meantime, the steroids are reduced to as low an amount as is practical. Steroids have many side effects, that are more common with longer administration.

Common ones in the short run i. Problems that can occur after longer administration, besides the ones that may appear above, include. The drugs that are most commonly used include: Drug Equivalent mg Half life Usual starting dose dexamethasone decadron 0.

Deterioration or temporary induction of diabetes, high blood sugar Sleeplessness, mood swings Problems that can occur after longer administration, besides the ones that may appear above, include Weight gain with swelling in ankles and fat accumulation around center of body, moon face.

Weakness in legs steroid myopathy Cataracts Increased risk of infections Suppression of adrenal glands, low blood pressure and other problems during taper. Bruising, thin skin. Byl FM. Sprague MS. Lesion-induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation. J Physiol ; Pt 1 Kitahara T. Kondoh K. Morihana T. Neurol Res ;25 3 Ohbayashi S. Oda M. Yamamoto M. Recovery of the vestibular function after vestibular neuronitis.

Acta Otolaryngol. Corticosteroids effect on vestibular neuritis symptom relief. Issa A. Golz A. Prednisone treatment for vestibular neuritis. Otol Neurotol. Zingler VC. Arbusow V. Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med.

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Prednisone for ear fullness.Steroid Treatments Equally Effective Against Sudden Deafness

 

Who is this information for? Corticosteroids are man-made drugs that work like cortisol, a natural steroid hormone in your body. These medicines reduce inflammation and alter the immune system.

They can be taken as tablets, or injected into the blood-stream or body tissues. Common examples of corticosteroids include: Prednisolone e. Sensorineural hearing loss new onset or sudden deterioration of pre-existing SNHL should be confirmed with an Audiogram prior to commencing CT. Therapeutic recommendations Corticosteroid Therapy is most beneficial the sooner it is started after symptoms onset. For Sudden Sensorineural Hearing Loss, corticosteroid use should start ideally within 72 hours of deafness onset 1 , and can be offered within 2 weeks of symptom onset as a primary treatment.

Salvage treatment, which is given to patients who did not receive or did not respond to primary treatment, is typically delivered weeks after the onset of symptoms. The most common method of administration is by mouth. We will not discuss intravenous administration faster and stronger, sometimes used for situations where symptoms are very severe such as bilateral deafness associated with autoimmune inner ear disease.

Administration through the ear-drum is discussed elsewhere. This method has the advantage of much less side effects, but the disadvantages of higher expense and the need for a subspecialty visit for injection through the ear drum.

For the oral method, there are four common protocols that we use in our clinic :. The easiest, safest, and most convenient method of trying steroids is to use a medrol methylprednisolone dose pack. This is a card that contains 6 days of steroids, with less provided each day. The gradual decrease in the amount of steroids each day is called a "taper".

The reason to do this is to allow the patient's adrenal glands, which are usually suppressed by the steroids, to gradually return to supplying steroids to the patient on their own. Medrol is slightly stronger than prednsone, so to convert this into "prednisone", when using the 4 mg dose-pack, one just has to multiple by 5.

In other words, the medrol dose pack is the equivalent of 30 mg of prednisone, tapering down to 0 over a week. For persons in whom a larger amount of steroids is indicated a longer protocol and more intense protocol is selected. Longer pulses require longer tapers. However, in a large proportion of patients, no known cause of the sudden hearing loss can be found. Steroids are commonly used to treat patients with sudden hearing loss of an unknown origin. The specific action of the steroids in the hearing apparatus is uncertain.

It is possible that the steroid treatment improves hearing because of its ability to reduce inflammation and oedema swelling in the hearing organs.

The review of the trials showed a lack of good-quality evidence for the effectiveness of steroids in the treatment of sudden hearing loss of an unknown origin. The quality of the trials was generally low and more research is needed. The value of steroids in the treatment of idiopathic sudden sensorineural hearing loss remains unclear since the evidence obtained from randomised controlled trials is contradictory in outcome, in part because the studies are based upon too small a number of patients.

This is an update of a Cochrane review first published in The Cochrane Library in Issue 1, and previously updated in Idiopathic sudden sensorineural hearing loss ISSHL is a clinical diagnosis characterised by a sudden deafness of cochlear or retrocochlear origin in the absence of a clear precipitating cause.

Steroids are commonly prescribed to treat this condition. More ». June 6, Injecting steroids into the middle ear works just as well as taking them orally when it comes to restoring hearing for sudden deafness patients. This finding, the result of a large clinical trial comparing the therapies, will help doctors choose the best treatment for patients with this condition.

Sudden deafness, also called sudden sensorineural hearing loss, is an emergency medical condition that affects several thousand people annually, usually between the ages of 40 and It often arises without an obvious cause and occurs in one ear all at once or over a period of up to 3 days.

Oral steroids, such as prednisone, are usually prescribed over the course of 2 weeks to restore hearing.

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- Prednisone for ear fullness

    For the oral method, there are four common protocols that we use in our clinic :. Next, we will move onto medications.

Before you begin using it always disclose the following to your time: If you are pregnant or discontinuing. If you suffer from any ingredients. If you have from any other acne conditions or illnesses. If you are using any other medicine (including all non-prescription).

More ». June 6, Injecting steroids into the middle ear works just as well as taking them orally when it comes to restoring hearing for sudden deafness patients. This finding, the result of a large clinical trial comparing the therapies, will help doctors choose the best treatment for patients with this condition. Sudden deafness, also called sudden sensorineural hearing loss, is an emergency medical condition that affects several thousand people annually, usually between the ages of 40 and It often arises without an obvious cause and occurs in one ear all at once or over a period of up to 3 days.

Oral steroids, such as prednisone, are usually prescribed over the course of 2 weeks to restore hearing. There is only a 2- to 4-week window of time for treatment before hearing loss becomes permanent. Recently, doctors have started injecting steroids directly into the middle ear — a procedure called intratympanic treatment. This technique is thought to deliver more of the drug to the ear and to avoid some of the side effects that can come along with oral steroids.

The side effects of oral therapy can be mild, like weight gain, mood changes and sleep disruption, or more serious, like high blood pressure and elevated blood sugar. Side effects of injected steroids are usually local, such as ear infection and vertigo. However, up until now, no study had compared the 2 treatments to see whether direct injection worked as well as oral steroids. To investigate, Dr.

Steven Rauch of Harvard Medical School and the Massachusetts Eye and Ear Infirmary led a team of investigators from 16 medical centers nationwide in a clinical trial involving more than patients. The results were published in the May 25,issue of the Journal of the American Medical Association. The study tested the treatments as they are usually given in the clinic. For oral steroid therapy, patients received 60 milligrams of prednisone for 14 days, followed by a tapering-off period of 5 days.

The other group was given 40 milligrams of methylprednisolone injected directly through the eardrum 4 times over the course of 2 weeks. The study followed the recovery of these patients for 6 months, measuring the success of the treatments based on hearing tests at the first and second weeks, and months 2 and 6. Under both regimens, patients recovered their hearing to about the same extent at 2 and 6 months.

The oral steroid patients experienced typical symptoms, such as sleep, mood and appetite changes. The injected steroid patients had pain at the injection site and vertigo; a few had ear infections and a perforated eardrum.

Most symptoms cleared up by 6 months. Nevertheless, the difference showed that while the treatments were equally effective, they might not be equally appropriate for every patient.

People with sudden deafness should discuss the risks and benefits of both treatments with their doctor. Site Menu Home. Search Health Topics. Search the NIH Guide. NIH Research Matters. Back to Top.

It often arises without an obvious cause and occurs in one ear all at once or over a period of up to 3 days. Oral steroids, such as prednisone. The glucocorticoids, prednisolone and dexamethasone, were the most effective in our study in reducing middle ear inflammation in response to bacterial challenge. It often arises without an obvious cause and occurs in one ear all at once or over a period of up to 3 days. Oral steroids, such as prednisone. The etiology is not certain, but the probable theories include viral, vascular or inner ear membrane rupture. Oral steroids medications within the first. Corticosteroids are man-made drugs that work like cortisol, a natural steroid hormone in your body. vertigo and / or unbalance and aural fullness. Lesion-induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation. These medicines reduce inflammation and alter the immune system. The reason to do this is to allow the patient's adrenal glands, which are usually suppressed by the steroids, to gradually return to supplying steroids to the patient on their own. Concerns or questions? Main results:. Phernagan: 25 mg orally or by rectal suppository Caution: Do not drive or operate heavy machinery while dizzy or taking above medication as they may impair your judgement and reflexes.

Jump to navigation. A sudden onset of hearing loss due to disease of the hearing organs is a medical emergency and requires prompt recognition and treatment. In addition to the hearing impairment, patients may also suffer from symptoms of tinnitus background ringing noise , a sensation of ear fullness and dizziness.

In many instances medical specialists are able to find the cause and treat the hearing impairment. However, in a large proportion of patients, no known cause of the sudden hearing loss can be found. Steroids are commonly used to treat patients with sudden hearing loss of an unknown origin. The specific action of the steroids in the hearing apparatus is uncertain. It is possible that the steroid treatment improves hearing because of its ability to reduce inflammation and oedema swelling in the hearing organs.

The review of the trials showed a lack of good-quality evidence for the effectiveness of steroids in the treatment of sudden hearing loss of an unknown origin. The quality of the trials was generally low and more research is needed.

The value of steroids in the treatment of idiopathic sudden sensorineural hearing loss remains unclear since the evidence obtained from randomised controlled trials is contradictory in outcome, in part because the studies are based upon too small a number of patients.

This is an update of a Cochrane review first published in The Cochrane Library in Issue 1, and previously updated in Idiopathic sudden sensorineural hearing loss ISSHL is a clinical diagnosis characterised by a sudden deafness of cochlear or retrocochlear origin in the absence of a clear precipitating cause. Steroids are commonly prescribed to treat this condition. There is no consensus on their effectiveness. To determine whether steroids in the treatment of ISSHL a improve hearing primary and b reduce tinnitus secondary.

The date of the most recent search was 22 April We identified all randomised controlled trials with or without blinding in which steroids were evaluated in comparison with either no treatment or a placebo. We considered trials including the use of steroids in combination with another treatment if the comparison control group also received the same other treatment. The two authors reviewed the full-text articles of all the retrieved trials of possible relevance and applied the inclusion criteria independently.

We graded trials for risk of bias using the Cochrane approach. The data extraction was performed in a standardised manner by one author and rechecked by the other author. Where necessary we contacted investigators to obtain the missing information.

Meta-analysis was neither possible nor considered appropriate because of the heterogeneity of the populations studied and the differences in steroid formulations, dosages and duration of treatment. We analysed and reported the quality of the results of each study individually.

A narrative overview of the results is presented. Only three trials, involving participants, satisfied the inclusion criteria and all three studies were at high risk of bias. One trial showed a lack of effect of oral steroids in improving hearing compared with the placebo control group. The third trial also showed a lack of effect of oral steroids in improving hearing compared with the placebo control.

However, this trial did not follow strict inclusion criteria for participant selection and analysis of data was limited by significant exclusion of participants from the final analysis and lack of participant compliance to the treatment protocol.

No clear evidence was presented in two trials about any harmful side effects of the steroids. Only one study declared that no patients suffered from adverse effects of the steroid treatment. Steroids for the treatment of sudden hearing loss with unknown cause A sudden onset of hearing loss due to disease of the hearing organs is a medical emergency and requires prompt recognition and treatment. Authors' conclusions:.

To determine the incidence of significant side effects from the medication. Search strategy:. Selection criteria:. Data collection and analysis:. Main results:. Health topics:.

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