Even low-dose steroids increase DMARD infection risk | MDedge Rheumatology.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. The mean number of months was 6. Three radiologists independently reviewed for scarring all DMSA scans that were of adequate quality.

For a given kidney, the presence or absence of scarring was the diagnosis endorsed by the majority of readers, i. For a given child, if either kidney or both kidneys were diagnosed with scarring by the majority of readers, then the child was determined to have renal scarring.

Scarring was assessed semi-quantitatively by dividing the renal cortex into 12 equal segments. Severe scarring was defined as greater than 4 affected renal segments or global atrophy, i. For a given kidney, the presence or absence of severe scarring was the diagnosis endorsed by the majority of readers, i.

For a given child, if either kidney or both kidneys were diagnosed with severe scarring by the majority of readers, then the child was determined to have severe renal scarring. For each radiologist, for each child, if either kidney or both kidneys were diagnosed with scarring, then the child was determined to have renal scarring. For each radiologist, the proportion of children with scarring in a given treatment group is the number of children diagnosed with scarring divided by the number of children in the treatment group.

The mean proportion of children with scarring in a given treatment group is the average proportion taken across the 3 radiologists. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think!

Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Results First Posted : July 2, Last Update Posted : July 2, View this study on Beta. Study Description.

In this study the investigators will determine whether corticosteroids given at the time of urinary tract infection help prevent permanent damage to the kidneys. Detailed Description:. Because host inflammatory response is the final and most important step in the formation of renal scars, the use of anti-inflammatory agents may be the best strategy to reduce renal scarring. In animal studies, the use of corticosteroids has been shown to be effective in preventing post-pyelonephritic scarring.

We will conduct a randomized, double-blind, placebo-controlled trial to determine the efficacy of 3 days of daily adjuvant dexamethasone on the incidence of renal scarring 4 to 6 months after a first febrile urinary tract infection UTI. We hypothesize that the proportion of children with UTI who develop renal scarring will be lower among children who are treated with both dexamethasone and antibiotics as compared with children treated with antibiotics alone. Drug Information available for: Dexamethasone Dexamethasone sodium phosphate Dexamethasone acetate.

FDA Resources. Arms and Interventions. Other Names: Prelone Orapred Corticosteroid. Outcome Measures. Renal scarring was defined as decreased uptake of tracer with or without loss of contours. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. More Information. Publications automatically indexed to this study by ClinicalTrials. Biomarkers for febrile urinary tract infection in children. Pediatr Nephrol. Epub Jul Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial. Epub Jun National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Drug: Placebo Drug: Dexamethasone. Phase 3. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Drug: Dexamethasone 0. Washington, District of Columbia, United States, R01DK U. July 12, Key Record Dates. Renal scarring Dexamethasone Child Corticosteroids.

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  This medication belongs to a class of drugs called corticosteroids. These powerful and fast-acting medications help reduce irritation and. Prednisolone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic.     ❾-50%}

 

- Description and Brand Names

    Abstract Background: Recent evidence indicates that prednisone can potentiate renal responsiveness to diuretics in heart failure HF. People with other autoimmune rheumatic diseases, cancer, or HIV were excluded. Federal Government. Actual Primary Completion Date :.

ATLANTA — Concomitant use of even low-dose steroids increases the risk of serious infections with antirheumatic drugs, according to a review of , Medicare patients by investigators at the University of Pennsylvania, Philadelphia. The crude incidence was 11 per person-years. After propensity-score weighting to balance out about 50 potential confounders, the predicted 1-year incidence of infection was 9.

George said. Related Glucocorticoids linked with surgical infections in RA patients. FDA Resources. Arms and Interventions. Other Names: Prelone Orapred Corticosteroid. Outcome Measures. Renal scarring was defined as decreased uptake of tracer with or without loss of contours.

Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. Publications automatically indexed to this study by ClinicalTrials.

Biomarkers for febrile urinary tract infection in children. Pediatr Nephrol. Epub Jul Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial. Epub Jun National Library of Medicine U.

National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Drug: Placebo Drug: Dexamethasone. Phase 3. There is a problem with information submitted for this request.

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Drug information provided by: IBM Micromedex. Prednisolone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation swellingsevere allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Prednisolone is a corticosteroid cortisone-like medicine or steroid.

It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. There is a problem with information submitted for this request. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID, plus expertise on managing health. To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you.

If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices.

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This medication belongs to a class of drugs called corticosteroids. These powerful and fast-acting medications help reduce irritation and. Prednisolone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic. However, high-dose prednisone induced a more potent renal sodium excretion and the hour urinary sodium excretion, at baseline, on day 5 and day Prednisone and bladder problems. It could be an excellent product for those that want to gain lean muscle mass and strength based on their experiences. This medication belongs to a class of drugs called corticosteroids. These powerful and fast-acting medications help reduce irritation and. Study Description. Pediatr Nephrol. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Outcome Measures.

Background: Recent evidence indicates that prednisone can potentiate renal responsiveness to diuretics in heart failure HF. However, the optimal dose of prednisone is not known. During this time, we recorded the hour urinary output and the hour urinary sodium excretion, at baseline, on day 5 and day Results: Low-dose prednisone significantly enhanced urine output. However, the effects of medium- and high-dose prednisone on urine output were less obvious.

As for renal sodium excretion, high-dose prednisone induced a more potent natriuresis than low-dose prednisone. Despite the potent diuresis and natriuresis induced by prednisone, serum creatinine, angiotensin II, and aldosterone levels were not elevated.

These favorable effects were not associated with an inflammatory suppression by glucocorticoids. Conclusions: Only low-dose prednisone significantly enhanced urine output.

However, high-dose prednisone induced a more potent renal sodium excretion than low-dose prednisone. Trial registration: ClinicalTrials. Abstract Background: Recent evidence indicates that prednisone can potentiate renal responsiveness to diuretics in heart failure HF. Associated data ClinicalTrials.